Importantly, these receptors were found to have already been activated by a wide array of endogenous opioids in a concentration similar to that observed for activation and signaling of classical opiate receptors. In turn, these receptors have been discovered to get scavenging action, binding to and decreasing endogenous amounts of opiates obtainabl
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Scientists have a short while ago identified and succeeded in synthesizing conolidine, a purely natural compound that demonstrates promise for a strong analgesic agent with a more favorable basic safety profile. Although the actual system of action stays elusive, it's at present postulated that conolidine might have various biologic targets. Presen